BioportTriComboUK patient and professional information

For UK healthcare professionals

Bioport TriCombo: a glucosamine, chondroitin and hyaluronate intra-articular injection.

A sterile, viscoelastic solution for intra-articular injection containing N-acetylglucosamine (30 mg/ml), chondroitin sodium sulfate (30 mg/ml) and sodium hyaluronate (16 mg/ml, 3 MDa) in a 2.25 ml pre-filled glass syringe. The hyaluronate and chondroitin sulfate are physically associated through hydrogen bonding; the product is not chemically or irradiation cross-linked.

A clinician at a workstation reviewing an ultrasound image of a knee

At a glance

Composition, presentation and schedule.

TriCombo combines glucosamine, as N-acetylglucosamine (NAG), with chondroitin sulfate and hyaluronic acid. Chondroitin sulfate and hyaluronate are glycosaminoglycans (GAGs); the hyaluronate is the lubricating component.1

Composition
Per ml: N-acetylglucosamine 30 mg, chondroitin sodium sulfate 30 mg, sodium hyaluronate 16 mg1
Presentation
2.25 ml pre-filled single-use glass syringe1
Hyaluronate molecular weight
3 MDa average1
Cross-linking
Physical association between hyaluronate and chondroitin sulfate; not chemically or irradiation cross-linked1
Schedule
One syringe per treatment; two treatment cycles per year1
Indication
Symptomatic treatment of mild to severe knee osteoarthritis1
Illustration of an injection into the knee joint space
Intra-articular injection into the knee joint

Single-injection format

Three ingredients, one syringe.

TriCombo supplies all three ingredients in one pre-filled syringe, given as a single intra-articular injection per treatment. The manufacturer recommends two treatment cycles per year, at six-month intervals.1

References

  1. 1.Nikovari Bio Tech Oy. Bioport TriCombo product brochure. Manufacturer document, 8 pages, 2025. View source