FAQ
Frequently asked questions about Bioport TriCombo.
Answers to common questions about Bioport TriCombo, an injection of glucosamine (as N-acetylglucosamine, NAG), chondroitin sulfate and hyaluronic acid, the lubricating component, given into the knee.
Common questions
Answers to what people ask before contacting a clinic.
What is Bioport TriCombo?
A glucosamine, chondroitin and hyaluronic acid injection given directly into the knee joint, supplied in one pre-filled syringe for a single injection. The manufacturer describes it as a joint-fluid supplement for the symptomatic treatment of knee osteoarthritis.1
Is it a steroid?
No. It contains glucosamine (as N-acetylglucosamine), chondroitin sulfate and hyaluronic acid. It is a different approach from a corticosteroid injection.1
Is this the same as glucosamine tablets?
The ingredient names will be familiar, but a tablet and an injection are different routes. A tablet is swallowed and has to reach the joint through the bloodstream; TriCombo is placed inside the knee itself.
Is it a single injection?
Yes. The product is presented as one injection per treatment. The manufacturer describes a six-month treatment interval, and any repeat is a decision made with your clinician at review.1
Does it hurt?
Every patient experiences an injection differently. Your clinician may use a local anaesthetic and can tell you what to expect. Some discomfort or swelling can occur afterwards; a knee that becomes hot, very swollen or very painful, particularly with fever, needs urgent medical assessment.
How long does it last?
The manufacturer describes a six-month treatment interval, with two treatment cycles a year. Response varies from person to person, so your clinician reviews how your knee has responded before any repeat injection.1
What are the risks?
Any joint injection can cause temporary pain, swelling or, rarely, infection. The manufacturer states that the absence of chemical or irradiation cross-linking is intended to reduce the chance of reactions after injection. Contraindications and warnings are in the instructions for use, which your clinician follows.1,3
Who is it for?
The manufacturer’s indication covers the symptomatic treatment of mild to severe knee osteoarthritis. Whether it is an option for your knee is decided by the clinician who examines you and looks at your scans.1
What is the extracellular matrix?
The material that cartilage cells build and live in: collagen fibres, proteoglycans carrying chondroitin sulfate, and hyaluronic acid, all holding water. Glucosamine is a building block the cells use to make those sugar chains. Three of those four components are the ingredients of TriCombo. The extracellular matrix page explains it in plain English.4,1
Where can I have it?
TriCombo is given in a clinic, by a clinician, after an assessment. The clinic currently offering it is listed on the where to have it page, with contact details.
How much does it cost?
Clinics set their own fees. Ask the clinic what the fee covers, including the consultation, the injection, any imaging and follow-up. No price is published on this website.
Can I have it if I have already had another injection?
Previous treatment is part of the assessment. Tell the clinician which product you received, when, and how your knee responded, so the next step can be planned appropriately.
Can I buy it myself?
No. TriCombo is for intra-articular injection by a physician. It is not sold to the public.1
Studies mentioned on this page
- 1.Nikovari Bio Tech Oy. Bioport TriCombo product brochure. Manufacturer document, 8 pages, 2025. View source
- 2.Iordan DA, Coman MG, Hrisca-Eva OD, Stavrică-George A, Gherghin AC, Onu I. Enhanced Synovial Fluid Rheology in Moderate Knee Osteoarthritis Through Combined Intra-Articular Hyaluronic Acid and Multimodal Physiotherapy: A Monocentric Observational Study. Journal of Clinical Medicine, 14(17):6051, 2025. View DOI
- 3.Nikovari Bio Tech Oy. Bioport TriCombo instructions for use. Supplied with each pack, 2025. View source
- 4.Sophia Fox AJ, Bedi A, Rodeo SA. The basic science of articular cartilage: structure, composition, and function. Sports Health, 1(6):461-468, 2009. View DOI
Still have a question?
For your own knee, talk to a clinic that offers TriCombo. For a question about this website, ask us.